Oncolytic Viruses and Novel Biologic Therapies
Oncolytic viruses are engineered or naturally occurring viruses that selectively infect and kill cancer cells while sparing normal tissue. They stimulate antitumor immune responses and can be combined with immunotherapy for enhanced efficacy. Talimogene laherparepvec (T-VEC) is an FDA-approved oncolytic virus for melanoma. Novel biologic therapies also include monoclonal antibodies, bispecific T-cell engagers, and fusion proteins, which harness the immune system to recognize and attack tumors. These therapies represent a shift toward precision immunotherapy, offering new hope for hard-to-treat cancers. Ongoing trials aim to refine delivery, enhance tumor specificity, and minimize immune-related side effects.
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