Cancer Stem Cells and Tumor Heterogeneity
Cancer stem cells (CSCs) are a subpopulation within tumors capable of self-renewal, differentiation, and tumor initiation. They contribute to therapy resistance, metastasis, and relapse. Tumor heterogeneity—genetic, phenotypic, and microenvironmental differences among cancer cells—complicates treatment response and disease progression. CSCs play a key role in this diversity. Targeting CSCs requires innovative approaches beyond conventional therapies, including epigenetic modulators and immunotherapies. Understanding the interplay between CSCs and the tumor microenvironment is vital to overcoming resistance and improving treatment durability. Addressing heterogeneity is essential for developing more effective, long-lasting cancer therapies.
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