Cancer Therapy & Radiation Oncology

Tumor Microenvironment and Radiosensitivity

The tumor microenvironment plays a critical role in influencing radiosensitivity and therapeutic response. This session explores how hypoxia, immune cell infiltration, stromal interactions, angiogenesis, and metabolic factors affect radiation outcomes. Advances in molecular profiling and functional imaging are improving understanding of how the microenvironment modulates DNA repair mechanisms and tumor resistance. Strategies targeting hypoxic regions, immune modulation, and radiosensitizers will be discussed, along with novel approaches combining radiation with immunotherapy to overcome resistance. Translational research identifying predictive biomarkers and microenvironment-driven treatment adaptation will be highlighted. By integrating biological insights with precision radiation techniques, clinicians can enhance tumor control while minimizing normal tissue damage. Understanding and targeting the tumor microenvironment represents a major step toward biologically optimized and personalized radiotherapy strategies with significant global clinical impact.