Targeted Therapy and Small Molecule Inhibitors

Targeted therapy aims to disrupt specific molecular pathways critical for cancer cell growth and survival. Small molecule inhibitors, a cornerstone of this approach, interfere with enzymes and proteins involved in cancer progression, such as tyrosine kinases and PI3K. These therapies offer higher specificity and reduced toxicity compared to conventional chemotherapy. Successful examples include imatinib for chronic myeloid leukemia and EGFR inhibitors for lung cancer. Resistance and off-target effects remain challenges, prompting research into next-generation inhibitors and combination regimens. Targeted therapies are central to personalized oncology, aligning treatment with individual genetic profiles for improved outcomes.

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